March 1, 1976Circulation ResearchOpen Access

The effect of lidocaine on diastolic transmembrane currents determining pacemaker depolarization in cardiac Purkinje fibers.

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Population

sheep Purkinje fibers

Design

Preclinical

Authors

FWFrancis M. WeldHighland Hospital JBJ. Thomas BiggerAllegheny College

Discussion

Member takes

Implication

May underlie lidocaine suppression of Purkinje automaticity in animals; hypothesis-generating for clinical antiarrhythmic mechanisms.

Structured PICO

Population

sheep Purkinje fibers

Intervention

lidocaine (1-5 mg/liter)

Outcome

diastolic currents, including magnitude and time course of activation and deactivation of the time- and voltage-dependent potassium pacemaker current (iK2), and steady state current-voltage relationshipsurrogate

Lidocaine decreases the slope of spontaneous diastolic depolarization in mammalian Purkinje fibers by diminishing the pacemaker current (iK2) and increasing steady state outward transmembrane current.

Cite This Study

Weld et al. (1976) studied this question.

synapsesocial.com/papers/6a9466bbce9e54907c6e4f6b https://doi.org/10.1161/01.res.38.3.203

View Full Paper

Ask AI

Bookmark

The effect of lidocaine on diastolic transmembrane currents determining pacemaker depolarization in cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of lidocaine on diastolic transmembrane currents determining pacemaker depolarization in cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider