October 1, 1985Circulation ResearchOpen Access

Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity.

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Population

sheep cardiac Purkinje fibers

Design

Preclinical

Authors

SSS S SheuUniversity of Rochester Medical Center WLW. J. LedererUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

Hypothesis-generating for lidocaine's antiarrhythmic mechanism in animals; human translation requires prospective study.

Structured PICO

Population

sheep cardiac Purkinje fibers

Intervention

lidocaine (20 microM = 5.4 micrograms/ml)

Outcome

electrical activity, intracellular sodium activity, and tensionsurrogate

Lidocaine exerts its negative inotropic and antiarrhythmic effects by decreasing inward sodium current, which reduces action potential duration and intracellular sodium and calcium activities.

Cite This Study

Sheu et al. (1985) studied this question.

synapsesocial.com/papers/6a1c824f0e2acd31eb2fd3f8 https://doi.org/10.1161/01.res.57.4.578

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Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider