September 15, 1996Circulation
Differential Effects of Changes in Local Myocardial Refractoriness on Atrialand Ventricular Latency
Why the study?
How do changes in myocardial refractoriness affect local conduction in the right atrial and ventricular myocardium?
Population
19 patients undergoing investigation of atrial and ventricular tachycardias through programmed electrical…
Comparison
Four pacing protocols with drive train pacing… vs Comparisons between different PCLs, DTDs, and…
Design
Other
Authors
Discussion
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Implication
May differentially modulate atrial vs ventricular arrhythmia risk during rate acceleration; leaves open mechanisms and clinical relevance.
Structured PICO
How do changes in myocardial refractoriness affect local conduction in the right atrial and ventricular myocardium?
P
Population
19 patients undergoing investigation of atrial and ventricular tachycardias through programmed electrical stimulation
I
Intervention
Four pacing protocols with drive train pacing cycle lengths (PCLs) of 600 and 400 milliseconds and drive train durations (DTDs) of 8 and 50 stimuli
C
Comparator
Comparisons between different PCLs (600 vs 400 ms), DTDs (8 vs 50 stimuli), and between atrial and ventricular myocardium
O
Outcome
Changes in effective, functional, and relative refractoriness and local conduction intervalssurrogate
Changes in myocardial refractoriness produce divergent effects on local conduction in the atrium versus the ventricle, which may influence arrhythmogenesis differently during heart rate acceleration.
Cite This Study
Fananapazir et al. (1996) studied this question.