Key result
In perfused guinea-pig hearts, premature ventricular activation induced immediately after the refractory period caused conduction slowing primarily due to increased activation latency (+54%).
Why the study?
What are the determinants of slowed conduction in premature ventricular beats induced during programmed stimulations in perfused guinea-pig hearts?
What are the determinants of slowed conduction in premature ventricular beats induced during programmed stimulations in perfused guinea-pig hearts?
In perfused guinea-pig hearts, prolonged activation latency at the stimulation site is the critical determinant of conduction slowing during premature ventricular beats.
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Should not change clinical arrhythmia management; leaves open whether activation latency drives conduction slowing in humans.
Oleg E. Osadchii (2018) studied Premature ventricular beats. Premature ventricular activation during programmed stimulation was evaluated on Activation latency and LV-to-RV delay. In perfused guinea-pig hearts, premature ventricular activation induced immediately after the refractory period caused conduction slowing primarily due to increased activation latency (+54%).
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