June 1, 1999Pacing and Clinical Electrophysiology

Change of Atrial Refractory Period after Short Duration of Rapid Atrial Pacing: Regional Differences and Possible Mechanisms

View Full Paper

Ask AI

Bookmark

Why the study?

Does rapid atrial pacing induce regional differences in atrial ERP shortening, and what are the effects of calcium and potassium channels on this phenomenon in opened-chest dogs?

Structured PICO

Does rapid atrial pacing induce regional differences in atrial ERP shortening, and what are the effects of calcium and potassium channels on this phenomenon in opened-chest dogs?

Population

Opened-chest dogs

Intervention

Rapid atrial pacing at 800 beats/min for 30 minutes, with or without pretreatment with nicorandil, d-sotalol, verapamil, or ryanodine

Comparator

Baseline (before pacing) and between different pretreatment groups

Outcome

Change in atrial effective refractory period (ERP) and monophasic action potential duration at 90% repolarization (APD90)surrogate

Short-duration rapid atrial pacing induces uniform atrial ERP shortening that is attenuated by calcium channel blockade (verapamil) and ryanodine, but not by potassium channel modulators.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Implicates calcium handling in acute atrial remodeling; hypothesis-generating for AF therapies, with no clinical implications yet.

Cite This Study

Lee et al. (1999) studied this question.

synapsesocial.com/papers/6a829f441d8eddfbf50f6891 https://doi.org/10.1111/j.1540-8159.1999.tb06817.x

View Full Paper

Ask AI

Bookmark

Change of Atrial Refractory Period after Short Duration of Rapid Atrial Pacing: Regional Differences and Possible Mechanisms

Structured PICO

Discussion

Implication

Cite This Study

Change of Atrial Refractory Period after Short Duration of Rapid Atrial Pacing: Regional Differences and Possible Mechanisms

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider