What does this research mean for the field?

During chronic rapid atrial pacing, the progression of electrical remodeling is spatially inhomogeneous across the atria, leading to temporal increases in refractory period dispersion that correlate with heightened atrial fibrillation inducibility, particularly in the left atrium. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2001Japanese Circulation JournalOpen Access

Inhomogeneity in the Appearance of Electrical Remodeling During Chronic Rapid Atrial Pacing

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Why the study?

Does continuous rapid atrial pacing cause inhomogeneous electrical remodeling across different atrial sites in a canine model?

Population

5 adult beagle dogs weighing 11-14.5 kg

Comparison

Continuous rapid atrial pacing delivered at the… vs Baseline and recovery phase

Design

Preclinical

Follow-up

14 days of pacing and 7 days of recovery

Authors

MMMasahiko MoriguchiToshiba (Japan)SNShinichi NiwanoElectrophysiology NYNaoto YoshizawaIwate University

Discussion

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Implication

Suggests transient AERP dispersion may heighten AF vulnerability in models; leaves open translation to human AF mechanisms.

Structured PICO

Does continuous rapid atrial pacing cause inhomogeneous electrical remodeling across different atrial sites in a canine model?

Population

5 adult beagle dogs weighing 11-14.5 kg

Intervention

Continuous rapid atrial pacing (400 beats/min) delivered at the right atrial appendage for 14 days

Comparator

Baseline (day 0) and recovery phase (7 days post-pacing)

Outcome

Changes in atrial effective refractory period (AERP), AERP dispersion (AERPd), atrial conduction time (CT), and inducibility of atrial fibrillation (AF)surrogate

Chronic rapid atrial pacing induces inhomogeneous electrical remodeling across the atria, with the left atrium showing greater vulnerability to AF induction, highlighting regional differences in arrhythmogenesis.

Limitations

Time and spatial resolution of evaluating points were limited
His-bundle ablation was not performed, so hemodynamic changes during rapid atrial pacing were not excluded
Hemodynamic factors (e.g., atrial pressure and atrial wall stress) were not monitored
Roles of changes in electrophysiological parameters in provoking AF were unclear
Rapid pacing from the left atrial site was not performed

Cite This Study

Moriguchi et al. (2001) studied this question.

synapsesocial.com/papers/6a15533379ff98d0de4e72ae https://doi.org/10.1253/jcj.65.335

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes

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Inhomogeneity in the Appearance of Electrical Remodeling During Chronic Rapid Atrial Pacing

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Inhomogeneity in the Appearance of Electrical Remodeling During Chronic Rapid Atrial Pacing

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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