Key result
Rapid atrial pacing in pulmonary veins significantly decreased L-type calcium current density compared to control (-3.21 vs -6.03 pA/pF, P<0.05), more pronounced than right atrial appendage pacing.
Absolute Event Rate: -3.21% vs -6.03%
p-value: p=<0.05
Rapid pacing in pulmonary veins induces more pronounced electrical remodeling (decreased I(Ca,L) and I(to) densities) compared to right atrial appendage pacing in a canine model, highlighting the crucial role of PVs in initiating AF.
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Greater PV remodeling in canine models; extends animal data on PV arrhythmogenesis but leaves open human translation.
Hafid et al. (2007) studied Atrial fibrillation (n=12). Rapid atrial pacing in pulmonary veins (PVs) or right atrial appendage (RAA) vs. Sham-operated control was evaluated on L-type calcium current (I(Ca,L)) density (p=<0.05). Rapid atrial pacing in pulmonary veins significantly decreased L-type calcium current density compared to control (-3.21 vs -6.03 pA/pF, P<0.05), more pronounced than right atrial appendage pacing.
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