Key result
Long-term rapid atrial pacing in dogs significantly increased the incidence of delayed after depolarization in pulmonary vein cardiomyocytes with pacemaker activity (59% vs 7%, P<0.001).
Why the study?
Does long-term rapid atrial pacing alter the electrophysiological characteristics and arrhythmogenic activity of pulmonary vein cardiomyocytes in dogs?
Population
Single pulmonary vein cardiomyocytes isolated from dogs
Comparison
Long-term rapid atrial pacing at 780 bpm for 6… vs Control dogs (no rapid atrial pacing)
Design
Preclinical
Follow-up
6 to 8 weeks
Authors
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May implicate PV DADs in AF maintenance in dogs; leaves open translation to human AF mechanisms.
Does long-term rapid atrial pacing alter the electrophysiological characteristics and arrhythmogenic activity of pulmonary vein cardiomyocytes in dogs?
Absolute Event Rate: 59% vs 7%
p-value: p=<0.001
Long-term rapid atrial pacing alters the electrophysiological characteristics of pulmonary vein cardiomyocytes, increasing their arrhythmogenic activity, which may facilitate the maintenance of atrial fibrillation.
Chen et al. (2001) studied Atrial fibrillation. Rapid atrial pacing (RAP) vs. Control was evaluated on Incidence of delayed after depolarization in PV cardiomyocytes with pacemaker activity (p=<0.001). Long-term rapid atrial pacing in dogs significantly increased the incidence of delayed after depolarization in pulmonary vein cardiomyocytes with pacemaker activity (59% vs 7%, P<0.001).
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