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November 1, 2000Cardiovascular ResearchOpen Access

Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation

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Population

Pulmonary veins isolated from 31 dogs

Comparison

In vitro exposure to cardioactive agents and… vs Pulmonary veins from healthy control dogs

Design

Preclinical

Follow-up

6-8 weeks (pacing duration)

Key result

Chronic rapid atrial pacing in dogs increased the incidence of spontaneously occurring tachyarrhythmias in pulmonary vein preparations compared to healthy controls (93% vs 12%).

Authors

JCJoseph C. Y. Chen

Discussion

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Overview

Supports pulmonary vein triggers in experimental AF; leaves open translation to human mechanisms.

Key Points

  • To examine the electrophysiological properties of excitable cells in canine pulmonary veins from healthy and chronically paced dogs, along with their responses to cardioactive agents.
  • Recorded transmembrane action potentials across multiple pulmonary vein sites isolated from 17 healthy dogs and 14 dogs subjected to chronic rapid atrial pacing (6–8 weeks at 780 bpm).
  • Evaluated spontaneous action potential characteristics and responses to pharmacological agents including adrenoceptor, ion channel, and purinergic modulators.
  • Early afterdepolarizations occurred in 93% of preparations from chronic rapid pacing dogs compared to 41% of preparations from control dogs.
  • Spontaneously occurring high-frequency (>8 Hz) tachyarrhythmias were observed in 93% of chronic pacing preparations compared to 12% of controls.
  • Spontaneous electrical activities were suppressed by beta-blockers, calcium channel blockers, adenosine, and acetylcholine, whereas tachyarrhythmias responded to sodium or potassium channel blockade and magnesium.

Structured PICO

P
Population
Pulmonary veins isolated from 31 dogs (17 healthy dogs and 14 dogs with chronic rapid atrial pacing at 780 bpm for 6-8 weeks)
I
Intervention
In vitro exposure to cardioactive agents (beta-blockers, calcium channel blockers, adenosine, acetylcholine, sodium/potassium channel blockers, magnesium) and electrical stimulation
C
Comparator
Pulmonary veins from healthy control dogs
O
Outcome
Electrophysiological characteristics including transmembrane action potentials, early afterdepolarizations, and spontaneous tachyarrhythmiassurrogate

Main Result

Absolute Event Rate: 93% vs 12%

Chronic rapid atrial pacing increases the arrhythmogenic activity of pulmonary veins, supporting their role as critical foci in the genesis of atrial fibrillation.

Cite This Study

Joseph C. Y. Chen (2000) studied Atrial fibrillation (n=31). Chronic rapid atrial pacing vs. Healthy dogs was evaluated on Incidence of spontaneously occurring tachyarrhythmias. Chronic rapid atrial pacing in dogs increased the incidence of spontaneously occurring tachyarrhythmias in pulmonary vein preparations compared to healthy controls (93% vs 12%).

synapsesocial.com/papers/6a0fbb512badbc352afe9eb7https://doi.org/10.1016/s0008-6363(00)00179-6
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