Key result
After cardioversion of chronic atrial fibrillation, atrial effective refractory periods were 206.3 ms on amiodarone vs 195.5 ms in washout (P<0.0001) and increased after 4 weeks of sinus rhythm.
Why the study?
Does the maintenance of sinus rhythm for 4 weeks after cardioversion of chronic atrial fibrillation reverse electrical remodeling by increasing the atrial effective refractory period?
Population
25 patients with chronic atrial fibrillation undergoing internal cardioversion.
Comparison
Measurement of atrial effective refractory… vs Baseline versus 4 weeks of sinus rhythm; also…
Design
Cohort
Follow-up
4 weeks
Authors
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Supports reverse atrial remodeling with 4-week sinus rhythm maintenance in chronic AF; extends animal data to humans but leaves open need for randomized confirmation.
Observational (n=25)
Does the maintenance of sinus rhythm for 4 weeks after cardioversion of chronic atrial fibrillation reverse electrical remodeling by increasing the atrial effective refractory period?
Absolute Event Rate: 206.3% vs 195.5%
p-value: p=<0.0001
Maintenance of sinus rhythm for 4 weeks after cardioversion of chronic atrial fibrillation leads to a significant increase in atrial ERP, indicating reverse electrical remodeling in humans.
Pandozi et al. (1998) conducted an observational in chronic atrial fibrillation (n=25). Amiodarone vs. Pharmacological washout was evaluated on Atrial effective refractory period (ERP) (p=<0.0001). After cardioversion of chronic atrial fibrillation, atrial effective refractory periods were 206.3 ms on amiodarone vs 195.5 ms in washout (P<0.0001) and increased after 4 weeks of sinus rhythm.
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