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May 1, 1999Cardiovascular ResearchOpen Access

Reversal of atrial electrical remodeling following cardioversion of long-standing atrial fibrillation in man

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Why the study?

Does cardioversion to sinus rhythm reverse atrial electrical remodeling in patients with chronic atrial fibrillation?

Population

19 patients with chronic atrial fibrillation of more than six months duration and 20 age-matched controls…

Comparison

Cardioversion to sinus rhythm with an external… vs Age-matched controls without a history of atrial…

Design

Cohort

Follow-up

4 days

Key result

Restoration of sinus rhythm following cardioversion of chronic atrial fibrillation gradually prolonged the shortened atrial effective refractory period and improved its impaired rate adaptation.

Authors

YWYu Wang

Discussion

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Member takes

Overview

Supports reversal of atrial remodeling after cardioversion; leaves open effects on outcomes before changing practice in chronic AF.

Study Design

Type

Observational (n=39)

Structured PICO

Does cardioversion to sinus rhythm reverse atrial electrical remodeling in patients with chronic atrial fibrillation?

P
Population
19 patients with chronic atrial fibrillation of more than six months duration (mean age 64 +/- 14 years) and 20 age-matched controls without a history of atrial tachyarrhythmia. Total n=39.
I
Intervention
Cardioversion to sinus rhythm with an external defibrillator, followed by pacing at cycle lengths of 300, 400, 500, 600, and 700 ms.
C
Comparator
Age-matched controls without a history of atrial tachyarrhythmia (for baseline comparison) and longitudinal self-comparison (post-cardioversion over 4 days).
O
Outcome
Atrial effective refractory periods (AERP) at right atrial appendage and distal coronary sinus, and rate adaptation response measured at 30 min post-cardioversion and daily for 4 days.surrogate

Restoration and maintenance of sinus rhythm via cardioversion in patients with chronic atrial fibrillation reverses atrial electrical remodeling, specifically by prolonging the atrial effective refractory period and improving rate adaptation.

Cite This Study

Yu Wang (1999) conducted an observational in Chronic atrial fibrillation (n=39). Cardioversion to sinus rhythm vs. Age-matched controls without a history of atrial tachyarrhythmia was evaluated on Atrial effective refractory period and its rate adaptation response. Restoration of sinus rhythm following cardioversion of chronic atrial fibrillation gradually prolonged the shortened atrial effective refractory period and improved its impaired rate adaptation.

synapsesocial.com/papers/6a0ee43b1c5e2d2319fa0b9fhttps://doi.org/10.1016/s0008-6363(99)00030-9
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