Key result
Random stimulation protocol characterizes APD restitution in guinea pig hearts in ~32 seconds.
Population
Guinea pig hearts (n=5) perfused and stained with di-4 ANEPPS
Design
Preclinical
Authors
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Time-efficient APD restitution mapping in guinea pigs supports preclinical research; leaves open clinical translation for arrhythmia risk assessment.
A random stimulation protocol enables comprehensive characterization of cardiac action potential duration restitution in just 32 seconds, demonstrating that APD depends on the history of up to six previous beats.
Choi et al. (2004) studied Cardiac action potential duration restitution (n=5). Random stimulation protocol was evaluated on Curve fit of APD with previous DIs and APDs. A random stimulation protocol in guinea pig hearts showed that up to six previous beats contributed to action potential duration curve fits (R > 0.8), characterizing restitution in 32 seconds.
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