Restitution Properties During Ventricular Fibrillation in the In Situ Swine Heart
Key result
Restitution and cardiac memory explain ~39% of action potential duration variability in a swine VF model.
- R2 0.39 ± 0.05
- n=6
Population
6 pigs (in situ swine heart model)
Design
Preclinical
Follow-up
up to 60 seconds
Authors
Discussion
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Member takes
Implication
Suggests APD determinants in swine VF; leaves open translation to human arrhythmia mechanisms and therapies.
Structured PICO
P
Population
6 pigs undergoing up to 60 seconds of ventricular fibrillation to assess restitution properties and cardiac memory.
E
Exposure
Transmembrane recordings from the anterior right ventricular wall during up to 60 seconds of ventricular fibrillation
O
Outcome
Action potential duration (APD60) predictability based on previous diastolic intervals (restitution) and previous APD60s (cardiac memory)surrogate
Main Result
Effect estimate: R2 0.39 ± 0.05
Both restitution (diastolic interval) and cardiac memory (previous action potential duration) are equally important in determining action potential duration during ventricular fibrillation, though they only account for 39% of its variability.
Cite This Study
Huang et al. (2004) studied Ventricular fibrillation (n=6). Ventricular fibrillation was evaluated on Action potential duration (APD60) variability (R2 0.39 ± 0.05). In an in situ swine model of ventricular fibrillation, both restitution and cardiac memory were important determinants of action potential duration, together accounting for 39% of its variability.