Key result
Restitution properties of cardiac action potential duration and conduction velocity contribute to reentrant wavefront breakup during fibrillation, suggesting a target for new preventive therapies.
Altering cardiac electrical restitution properties represents a promising theoretical approach to preventing fibrillation.
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Identifies restitution properties as a potential therapeutic target in fibrillation; leaves open development and testing of targeted interventions.
Combined experimental and theoretical work has shown that restitution properties of the cardiac action potential duration and conduction velocity contribute to breakup of reentrant wavefronts during cardiac fibrillation independent of preexisting electrophysiologic heterogeneities in the tissue. Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation.
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Weiss et al. (2002) conducted a review in Cardiac fibrillation. Therapies altering cardiac electrical restitution properties was evaluated. Restitution properties of cardiac action potential duration and conduction velocity contribute to reentrant wavefront breakup during fibrillation, suggesting a target for new preventive therapies.
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