Key result
Anterior transmural MI leads to ~22% increase in LVEDV at one year.
Why the study?
Time-dependent changes in global left ventricular chamber volume and myocardial muscle mass after transmural myocardial infarction in humans were not fully characterized.
Population
18 patients with initial transmural myocardial infarction (12 anterior, 6 inferior) without heart failure
Comparison
Changes in left ventricular chamber volume and muscle mass over time after infarction
Design
Cohort study with serial cine computed tomographic scanning
Follow-up
1 year
Authors
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Following a moderate to large anterior myocardial infarction, left ventricular chamber dilation occurs progressively over the first year, while muscle mass initially decreases and then returns to baseline, suggesting elevated ventricular wall tension.
Cohort (n=18)
Absolute Event Rate: 180% vs 148%
p-value: p=< 0.001
Following a moderate to large anterior myocardial infarction, left ventricular chamber dilation occurs progressively over the first year, while muscle mass initially decreases and then returns to baseline, suggesting elevated ventricular wall tension.
Rumberger et al. (1993) conducted a cohort in Transmural myocardial infarction (n=18). Transmural myocardial infarction vs. Baseline (hospital discharge) was evaluated on Left ventricular end-diastolic volume in anterior myocardial infarction (p=< 0.001). Following anterior transmural myocardial infarction, left ventricular end-diastolic volume progressively increased from 148 ml at hospital discharge to 180 ml at 1 year (p < 0.001).
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