Key result
Real-time cardiac MRI linked to ~65% shorter study times than conventional cine MRI with comparable measurements.
Why the study?
Conventional cardiac MRI techniques for assessing left ventricular volume and mass are relatively slow and require ECG gating and breath-holding, limiting efficiency.
Does real-time cardiac MRI provide accurate measurements of LV volume and mass compared to conventional cine MRI in healthy volunteers and heart failure patients?
Observational (n=23)
Does real-time cardiac MRI provide accurate measurements of LV volume and mass compared to conventional cine MRI in healthy volunteers and heart failure patients?
Real-time cardiac MRI provides accurate and time-efficient measurements of left ventricular volume and mass without the need for breath-holding or ECG gating.
OBJECTIVES: The purpose of this study was to validate cardiac measurements derived from real-time cardiac magnetic resonance imaging (MRI) as compared with well-validated conventional cine MRI. BACKGROUND: Although cardiac MRI provides accurate assessment of left ventricular (LV) volume and mass, most techniques have been relatively slow and required electrocardiogram (ECG) gating over many heart beats. A newly developed real-time MRI system allows continuous real-time dynamic acquisition and display without cardiac gating or breath-holding. METHODS: Fourteen healthy volunteers and nine patients with heart failure underwent real-time and cine MRI in the standard short-axis orientation with a 1.5T MRI scanner. Nonbreath-holding cine MRI was performed with ECG gating and respiratory compensation. Left ventricular end-diastolic volume (LVEDV), left ventricular endsystolic volume (LVESV), ejection fraction (EF) and LV mass calculated from the images obtained by real-time MRI were compared to those obtained by cine MRI. RESULTS: The total study time including localization for real-time MRI was significantly shorter than cine MRI (8.6 +/- 2.3 vs. 24.7 +/- 3.5 min, p < 0.001). Both imaging techniques yielded good quality images allowing cardiac measurements. The measurements of LVEDV, LVESV, EF and LV mass obtained with real-time MRI showed close correlation with those obtained with cine MRI (LVEDV: r = 0.985, p < 0.001; LVESV: r = 0.994, p < 0.001; EF: r = 0.975, p < 0.001; LV mass: r = 0.977, p < 0.001). CONCLUSIONS: Real-time MRI provides accurate measurements of LV volume and mass in a time-efficient manner with respect to image acquisition.
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Kaji et al. (2001) conducted an observational in Heart failure and healthy volunteers (n=23). Real-time cardiac magnetic resonance imaging (MRI) vs. Conventional cine MRI was evaluated on Total study time and correlation of cardiac measurements (LVEDV, LVESV, EF, LV mass) (p=<0.001). Real-time cardiac MRI significantly reduced total study time compared to conventional cine MRI (8.6 vs 24.7 min, p<0.001) and yielded highly correlated measurements of LV volume, mass, and EF.
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