Why the study?
Does endogenous endothelin-1 mediate angiotensin II-induced hypertrophy in cultured rat cardiomyocytes?
Does endogenous endothelin-1 mediate angiotensin II-induced hypertrophy in cultured rat cardiomyocytes?
Endogenous endothelin-1 acts as an autocrine/paracrine factor mediating angiotensin II-induced cardiac hypertrophy in rat cardiomyocytes.
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ET-1 mediation of Ang II hypertrophy is unproven in humans; extends rodent cardiomyocyte data but leaves open clinical translation.
Ito et al. (1993) studied this question.
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