April 1, 1993Clinical Science

Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins

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Why the study?

Does local production of nitric oxide or prostacyclin regulate endothelin-1-induced venoconstriction in healthy subjects?

Population

6 healthy subjects

Comparison

Local dorsal hand vein infusion of endothelin-1… vs Endothelin-1 infusion alone

Design

Other

Follow-up

60 min

Authors

WHWilliam G. HaynesOregon National Primate Research Center DWDavid J. WebbBrigham and Women's Hospital

Discussion

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Implication

Prostacyclin attenuates ET-1 venoconstriction in healthy veins; hypothesis-generating for endothelial regulation in disease.

Structured PICO

Does local production of nitric oxide or prostacyclin regulate endothelin-1-induced venoconstriction in healthy subjects?

Population

6 healthy subjects

Intervention

Local dorsal hand vein infusion of endothelin-1 (5 pmol/min) for 60 min co-infused with glyceryl trinitrate, prostacyclin, NG-monomethyl-L-arginine, or after oral administration of aspirin

Comparator

Endothelin-1 infusion alone

Outcome

Venoconstriction (maximal constriction %)surrogate

Endothelial production of prostacyclin, but not nitric oxide, attenuates endothelin-1-induced venoconstriction in human veins in vivo.

Cite This Study

Haynes et al. (1993) studied this question.

synapsesocial.com/papers/69fea847c28c7d12f5f0ca83 https://doi.org/10.1042/cs0840427

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Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider