What question did this study set out to answer?

This study aims to evaluate mortality and changes in prognostic profiles during the waiting period for aortic valve replacement in severe aortic stenosis patients.

December 1, 1996The Thoracic and Cardiovascular Surgeon

Mortality and Worsening of Prognostic Profile During Waiting Time for Valve Replacement in Aortic Stenosis

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Why the study?

What is the mortality and risk of prognostic worsening during the waiting time for aortic valve replacement in patients with severe aortic stenosis?

Population

99 consecutive patients with operative indication due to severe aortic stenosis, mean age 61 years, 58 men…

Comparison

Waiting on a surgical list for aortic valve… vs Post-aortic valve replacement period

Design

Cohort

Follow-up

Average 6.3 months waiting time; mean 5.7 years post-AVR

Authors

OLOle LundSemmelweis University TNTine Bjørn NielsenOdense University Hospital KEK. EmmertsenAarhus University Hospital

Discussion

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Implication

Waiting-list mortality was associated with delayed AVR in severe AS; leaves open whether expedited intervention improves outcomes.

Key Points

This study aims to evaluate mortality and changes in prognostic profiles during the waiting period for aortic valve replacement in severe aortic stenosis patients.
Prospective study with 99 patients indicated for surgery due to severe aortic stenosis.
Patients categorized into three groups based on outcomes during waiting time.
Logistic regression used to identify predictors of death and prognosis worsening.
Waiting-list death rate was 13.5% per year compared to 4.9% post-AVR (p < 0.05).
Group II patients' observed 7-year post-AVR survival was 60%, lower than predicted probabilities.
Factors such as high age, short symptom duration, and deranged diastolic function predicted worse outcomes.

Structured PICO

What is the mortality and risk of prognostic worsening during the waiting time for aortic valve replacement in patients with severe aortic stenosis?

Population

99 consecutive patients with operative indication due to severe aortic stenosis (AS), mean age 61 years, 58 men and 41 women.

Intervention

Waiting on a surgical list for aortic valve replacement (average 6.3 months)

Comparator

Post-aortic valve replacement period

Outcome

Death on the waiting list and worsening of prognostic profilehard clinical

A surgical waiting time averaging 6 months for aortic valve replacement in severe aortic stenosis is associated with a high mortality rate and worsening prognostic profile, emphasizing the need for timely intervention.

Limitations

Predictive models did not allow sufficiently accurate identification of the patients at risk during the waiting-time

Cite This Study

Lund et al. (1996) studied this question.

synapsesocial.com/papers/69fea899c28c7d12f5f0cbed https://doi.org/10.1055/s-2007-1012039

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Mortality and Worsening of Prognostic Profile During Waiting Time for Valve Replacement in Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Mortality and Worsening of Prognostic Profile During Waiting Time for Valve Replacement in Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider