What question did this study set out to answer?

This research aims to compare the antifungal susceptibility and stress adaptability of clinical and non-clinical Talaromyces marneffei strains.

May 9, 2026Frontiers in Fungal BiologyOpen Access

Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and diminished antifungal responsiveness relative to non-clinical strains

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Authors

KPKai-Su PanGuangxi Medical University SJSiwen JiangGuangxi Medical University DZDong-Yan ZhengGuangxi Medical University

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Implication

Randomized trial compares antifungal susceptibility and stress response of clinical and non-clinical T. marneffei strains, suggesting important adaptations.

Key Points

This research aims to compare the antifungal susceptibility and stress adaptability of clinical and non-clinical Talaromyces marneffei strains.
Evaluated 196 T. marneffei strains using broth microdilution and Sensititre YeastOne methods for MIC determination.
Assessed stress adaptability with 20 clinical and 20 non-clinical strains under conditions involving KCl, Congo red, H2O2, and Calcofluor white.
Clinical strains exhibited higher geometric mean MICs for most antifungals compared to non-clinical strains.
Non-clinical strains showed significantly less adaptability to stress than clinical strains, with notable p<0.05 for lower colony diameters and slower growth.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/69fece1db9154b0b82875cbd https://doi.org/10.3389/ffunb.2026.1838799

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Implication

Randomized trial compares antifungal susceptibility and stress response of clinical and non-clinical T. marneffei strains, suggesting important adaptations.

Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and diminished antifungal responsiveness relative to non-clinical strains

Discussion

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Implication

Key Points

Cite This Study

Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and diminished antifungal responsiveness relative to non-clinical strains

Discussion

Member takes

Implication

Key Points

Cite This Study

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