Friedel–Crafts Reaction of Arenes by Oxidatively Generated Metal Carbene: Divergent Synthesis of Polycyclic Aromatic Hydrocarbons via Controllable Cyclization of Ynones

Key Points

• This study aims to explore the synthesis of challenging quaternary carbons using Friedel-Crafts reactions.
• Utilized gold catalysis to facilitate the reaction.
• Focused on oxidatively generated metal carbene as a key intermediate.
• Targeted the controllable cyclization of ynones.
• Successfully formed synthetically challenging quaternary carbons under gold catalysis.
• Achieved a divergent synthesis of polycyclic aromatic hydrocarbons.
• Showed exclusive formation of the desired products during the reactions.