ABS TRACT Objective: Wound healing dynamics following endoscopic surgery play a crucial role in minimizing postoperative scarring, maintaining the patency of the drainage pathways, and promoting the regeneration of the functional epithelium.This study aimed to investigate the effects of inserting a topical antibiotic-impregnated gelatin sponge into the nasal cavity on the wound healing process.Material and Methods: Thirty-two rats underwent controlled injury to the left nasal mucosa using a standardized brushing technique.The subjects were randomly assigned to 4 groups (n=8 per group).Group 1 served as the control and received no additional intervention.In Groups 2, 3, and 4, gelatin sponges, either plain (Group 2), impregnated with nitrofurazone (Group 3), or with bacitracin-neomycin (Group 4) were applied to the injured mucosa within the nostrils.All animals were sacrificed on Day 21, and histopathological evaluation was performed to assess wound healing parameters.Results: Significant differences were found across all groups (p<0.05).Compared with the control group, the bacitracinneomycin group showed improvements in all parameters (p<0.05).The nitrofurazone group demonstrated reduced inflammatory cell infiltration, epithelial thickness index, subepithelial thickness index, and subepithelial fibrosis, with increased goblet cell count and neovascularization (p<0.05).The gelatin sponge group differed only in the subepithelial thickness index (p<0.05).Compared with the gelatin sponge group, the nitrofurazone group showed better outcomes in inflammation, epithelial thickness index, and neovascularization (p<0.05).Conclusion: The application of nitrofurazoneor bacitracin-neomycin-impregnated gelatin sponges may contribute to improved tissue regeneration, reduced fibrosis, and limited hypertrophic changes during the late phases of wound healing.
BUCAĞA et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: