Epitope mapping of Treponema Pallidum by SPOT synthesis combined with microscale thermophoresis to guide the development of chimeric antigens for syphilis immunodiagnostics

Puntos clave

• The research aims to map epitopes of Treponema pallidum to inform the design of chimeric antigens for syphilis diagnosis.
• Used SPOT synthesis for epitope mapping.
• Employed microscale thermophoresis to analyze binding interactions.
• Focused on developing chimeric antigens for immunodiagnostics.
• Identified key epitopes for Treponema pallidum.
• Developed potential chimeric antigens that could enhance syphilis detection.