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May 9, 2026Molecular CancerOpen Access

Non-coding RNAs as master regulators of ferroptosis in cancer: mechanisms and clinical implications

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Authors

HMHaoyang MoYXYao XieHZHao Zhang Hao Zhang

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Overview

This review explores how non-coding RNAs influence ferroptosis in cancer, suggesting new therapeutic targets.

Key Points

  • The aim is to elucidate the role of non-coding RNAs in regulating ferroptosis and their implications in cancer therapy.
  • A comprehensive review of current literature on the interactions between non-coding RNAs and ferroptosis.
  • Analysis of non-coding RNA involvement in the regulation of ferroptosis-related genes and pathways.
  • Exploration of clinical implications of targeting non-coding RNAs for overcoming drug resistance.
  • Non-coding RNAs form a regulatory network impacting ferroptosis-related genes and metabolic pathways.
  • These RNAs play a significant role in tumor microenvironment interactions among cancer, stromal, and immune cells.
  • Ferroptosis-related non-coding RNAs represent promising targets for immunotherapy and enhance efficacy against drug resistance.

Cite This Study

Mo et al. (2026) studied this question.

synapsesocial.com/papers/69fecf16b9154b0b82876321https://doi.org/10.1186/s12943-026-02666-x
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