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May 16, 2026Non-coding RNA ResearchOpen Access

Targeting non-coding RNAs in the ferroptosis system: Molecular mechanisms and clinical translation for reversing doxorubicin resistance in breast cancer

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Authors

XYXiaojie YuAXAn XuLYLongdi Yao

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Overview

Review summarizes how non-coding RNAs modulate doxorubicin resistance in breast cancer, implying potential new treatments.

Key Points

  • This review aims to elucidate the role of non-coding RNAs in modulating ferroptosis and doxorubicin resistance in breast cancer.
  • Summarized mechanisms of ferroptosis and doxorubicin resistance in breast cancer.
  • Outlined the roles of miRNAs, lncRNAs, and circRNAs in ferroptotic vulnerability.
  • Reviewed potential clinical applications of targeting ncRNAs for reversing drug resistance.
  • Aberrant ncRNA expression enhances ferroptosis resistance by affecting the antioxidant axis and iron homeostasis.
  • Targeting specific ncRNAs can restore sensitivity to doxorubicin in breast cancer cells.
  • NcRNAs present opportunities for development as biomarkers and therapeutic targets.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a080a71a487c87a6a40c6b9https://doi.org/10.1016/j.ncrna.2026.04.003
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