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May 7, 2026Organic Letters

Synthesis of Densely Substituted Spirocyclobutanes from Activated Alkenes and Sulfur Ylides

Maksim A. Boichenko Timur P. Tikhonov Vitaly V. Shorokhov Danila S. Lebedev Ernal R. Gaiazov Sergey S. Zhokhov Victor A. Tafeenko Nina K. Ratmanova Igor V. Trushkov Ivan A. Andreev Olga A. Ivanova

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Key Points

This research aims to understand the mechanisms that lead to high reactivity and diastereoselectivity in spirocyclobutane synthesis using sulfur ylides and alkenes.
Conducted preliminary mechanistic studies.
Analyzed the reaction between activated alkenes and sulfur ylides.
Reactivity was found to be significantly high in the synthesized spirocyclobutanes.
Marked diastereoselectivity was observed during the synthesis, indicating potential control over product formation.

Implication

Preliminary mechanistic studies reveal high reactivity and diastereoselectivity in spirocyclobutane synthesis.

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Cite This Study

Boichenko et al. (2026) studied this question.

synapsesocial.com/papers/69fecf71b9154b0b828765a7 https://doi.org/10.1021/acs.orglett.6c01386

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