Metal-Free, Iodine/DMSO-Promoted Oxidative C(sp 2 )-H Difunctionalization: Synthesis of Aminochalcogenylated Indoles

Satyajit Pal; S. SARKAR; Tanmay Pramanik; Anindita Mukherjee; Sougata Santra; Grigory V Zyryanov; Adinath Majee

doi:10.1039/d6ob00362a

January 1, 2026Organic & Biomolecular Chemistry

Metal-Free, Iodine/DMSO-Promoted Oxidative C(sp 2 )-H Difunctionalization: Synthesis of Aminochalcogenylated Indoles

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Key Points

This research aims to establish a metal-free method for the oxidative difunctionalization of indole compounds.
Utilized iodine and DMSO as primary reagents for the process.
Developed a protocol that is environmentally friendly and efficient.
Successful synthesis of aminochalcogenylated indoles without metal catalysts.
Demonstrated improved efficiency in creating complex indole derivatives.

Implication

Metal-free method achieves oxidative difunctionalization of indole using iodine and DMSO, indicating environmentally friendly synthesis.

Abstract

A metal-free approach has been developed for the oxidative difunctionalization of indole moieties using iodine and DMSO as the primary reagents. This protocol facilitates a metal-free, environmentally friendly, and efficient...

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Cite This Study

Pal et al. (2026) studied this question.

synapsesocial.com/papers/69fecf71b9154b0b82876621 https://doi.org/10.1039/d6ob00362a

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Metal-Free, Iodine/DMSO-Promoted Oxidative C(sp 2 )-H Difunctionalization: Synthesis of Aminochalcogenylated Indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

Metal-Free, Iodine/DMSO-Promoted Oxidative C(sp 2 )-H Difunctionalization: Synthesis of Aminochalcogenylated Indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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