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This review aims to explore the implications of cellular heterogeneity in hiPSC derivatives and its impact on disease modeling and therapies.

May 9, 2026Stem CellsOpen Access

Application of hiPSCs for tissue modeling and therapy: are we on track?

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This review aims to explore the implications of cellular heterogeneity in hiPSC derivatives and its impact on disease modeling and therapies.
Summarizes current knowledge on cellular heterogeneity origins in hiPSCs.
Discusses differentiation protocol improvements involving novel media, biomaterials, and 3D culture methods.
Outlines recommendations for standardization and best practices in stem cell research.
Increased understanding of heterogeneity is crucial for developing reliable tissue models and effective therapies.
Standardization of hiPSC methodologies is recommended to enhance reproducibility.
Advancements in AI and analytical tools may refine the identification of cell types in heterogeneous populations.

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Review highlights stem cell heterogeneity implications for modeling and therapy, emphasizing methodological advancements and analytical strategies.

Maunu et al. (2026) studied this question.

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Review highlights stem cell heterogeneity implications for modeling and therapy, emphasizing methodological advancements and analytical strategies.