255 Expanding rural access to colorectal cancer screening: Implementation of an FDA-approved blood-based test through a mobile health unit in Louisiana

Objectives/Goals: To describe the early implementation of the FDA-approved Shield blood-based colorectal cancer screening test using a mobile health unit serving rural Louisiana, assessing population reach and acceptability of the test. Methods/Study Population: This is a secondary analysis of implementation data collected by the Partners in Wellness (PIW) Mobile Health Unit between February and August 2025. The mobile unit includes a designated blood-draw space where specimens were collected by a trained phlebotomist or a registered nurse following standardized procedures. Adults aged ≥45 years were eligible. De-identified demographic information and Shield test results were analyzed descriptively. All individuals with positive results were referred for colonoscopy, and those with inconclusive results were offered Cologuard stool-based testing. One participant declined the stool-based testing. Results/Anticipated Results: A total of 77 individuals completed Shield testing the mean age was 59.5 years (range 30.6–89.9). Most were female (98.7%), representing 31 rural cities and one urban city. Racial/ethnic distribution included African American (33), White (26), Hispanic/Latino (16), Pacific Islander (5), and Asian (1) participants. Test outcomes were negative (87%), positive (10%), and inconclusive (3%). All positive participants were referred for colonoscopy. Among inconclusive cases, two were offered stool-based testing and one declined. Implementation was well accepted and demonstrated operational feasibility within mobile health services. Discussion/Significance of Impact: Integrating an FDA-approved blood-based colorectal cancer screening test into a mobile health program demonstrates a scalable and innovative strategy to reach medically underserved populations. This model can transform rural screening delivery and advance cancer health equity.