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May 9, 2026JBMR Plus0 citationsOpen Access

Brain and Knee Joint Degeneration After ACL Injury in Alzheimer's Disease Mice

Brain and Knee Joint Degeneration Following Anterior Cruciate Ligament Injury in a Mouse Model of Alzheimer’s Disease

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Authors

WYWei YaoBWBarton L. WiseYLYu‐Yang Lin

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Overview

Randomized trial investigates brain and knee joint degeneration in mice with Alzheimer's and ACL injury, suggesting shared disease mechanisms.

Key Points

  • The study aims to explore the relationship between knee joint degeneration and cognitive decline in a mouse model of Alzheimer's Disease.
  • Investigated brain and knee joint degeneration in APP/PS1 double transgenic and wild-type mice after non-invasive ACL rupture.
  • Conducted neurocognitive tests including open field, novel object recognition, and Morris water maze 6 weeks post-injury.
  • Quantified osteophyte formation and analyzed beta amyloid and phosphorylated tau levels in brain and knee joints at 6 weeks post-injury.
  • Female APP/PS1-OA mice exhibited significantly more osteophyte formation than WT-OA mice.
  • Increased levels of beta amyloid and phosphorylated tau were found in the brain and knee joints of APP/PS1-OA mice compared to WT or APP/PS1-Sham mice.
  • Findings suggest a connection between OA-related inflammation and cognitive dysfunction.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69fecfafb9154b0b82876ab6https://doi.org/10.1093/jbmrpl/ziag085
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