289 What patients want from research partnerships: A cross-sectional survey study

Objectives/Goals: This study surveyed Michigan Medicine patients to explore their interest and willingness to serve as research partners #_msocom_1 (patients who collaborate with academic researchers) and to identify their preferred research engagement activities, preferences for working with researchers, and perceived barriers and facilitators to collaboration. #_msoanchor_1. Methods/Study Population: We selected a random sample of 2,000 adult Michigan Medicine patients. A modified Dillman method was used, including initial mailing with a $10 gift, postcard reminder, and additional outreach for non-responders (mail, phone, or online survey). Survey questions covered demographics and health literacy, trust in medical researchers, and interest, preferences, obstacles, and facilitators to partnering. Variables were summarized descriptively, and associations between patient-level factors and interest in more versus less intensive partnership (>1 hour/month vs 1 hour/month or less) were quantified using logistic regression (adjusted for age and sex). Results/Anticipated Results: Of the N=2000 sample, 1633 were response-eligible. Of these, N=408 (25%) responded, with N=258 (63%) endorsing being interested in partnering. Average age was 51 years; 59% identified as female; 44% White, 19% Black, 9% Asian, 6% Hispanic/Latino, 6% Middle Eastern/North African, and 12% multiracial and/or multiethnic. Factors associated with interest in more time-intensive partnership (41% of responders) were having greater trust in researchers and being interested in helping identify research topics, assist with recruitment, and help disseminate findings. Transportation issues were the most reported obstacle (57%); personal experience with the medical topic was the most reported facilitator (76%). Health literacy level was not associated with willingness to engage in high time–intensity partnership. Discussion/Significance of Impact: This study identified factors that may affect patients’ willingness to engage as research partners, highlighting that those with lower literacy may still desire collaborations. Findings will contribute to development of a training program to support effective collaboration between patients and researchers.