Demonstrates enhanced bone regeneration through MSCs-macrophage communication, suggesting material innovation.
slow-release mechanisms to create a "fast-slow biphasic" ionic flow release, thereby establishing a dynamic alkaline ionic flow microenvironment. Within this microenvironment, 5B5Sr-SUIF recruits MSCs and stimulates MSCs to enhance the expression of miR-466m-5p, thereby obstructing the nuclear translocation of NF-κB in macrophages. This facilitates immunological regulatory communication between mesenchymal stem cells and macrophages, offering novel material design principles and molecular mechanism support for the exact regeneration of complicated bone deformities.
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Lu et al. (2026) studied this question.
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