Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 9, 2026Sage Open Chronic Disease

Specificity of non-motor symptoms of Parkinson’s disease: A systematic review and meta-analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

HJHolly JacksonUniversity Hospital of GenevaJAJudith Anzures-CabreraRoche (United Kingdom)RARayo AkandeRoche (Switzerland)

Discussion

Loading...

Member takes

Implication

Systematic review identifies specific non-motor symptoms of Parkinson’s disease in adults, suggesting better screening methods.

Key Points

  • This research aims to identify non-motor symptoms specific to Parkinson’s disease when compared to controls without neurological diseases.
  • Conducted a systematic review and meta-analysis of 15 studies
  • Included a total of 7393 Parkinson's disease patients and 2742 controls
  • Used random effects model to generate pooled prevalence risk ratios for symptoms.
  • 28 out of 30 non-motor symptoms were more common in the Parkinson’s disease population.
  • Excessive drooling had a risk ratio of 7.30 (95% CI 5.05–10.57).
  • Visual hallucinations showed a risk ratio of 6.48 (95% CI 3.61–11.64).

Cite This Study

Jackson et al. (2026) studied this question.

synapsesocial.com/papers/69fed021b9154b0b828772c9https://doi.org/10.1177/27558428261419700
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson’s Disease in Lithuania2024 · 5 citations
  2. 2The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.1988 · 3,525 citations
  3. 3The metric properties of a novel non‐motor symptoms scale for Parkinson's disease: Results from an international pilot study2007 · 1,107 citations
  4. 4Exploring Braak’s Hypothesis of Parkinson’s Disease2017 · 404 citations
  5. 5Non-motor symptoms in essential tremor, akinetic rigid and tremor-dominant subtypes of Parkinson’s disease2021 · 30 citations