Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study

Q: What is the clinical evidence from this study?

Population: Anthracycline-induced cardiotoxicity (n=31). Intervention: Cardiac MRI parameters (native T1 and ECV). Primary outcome: Early mortality (before 12 weeks).

Na Young Kim; Jinho Park; Heae Surng Park; Yong Wook Kim; Ji Won Kim; Jung Im Jung; Eun-Ju Kang; Kyunghwa Han; Chul Hwan Park; Peder E. Z. Larson; Y J Hong

doi:10.1148/ryct.240525

May 7, 2026Radiology Cardiothoracic Imaging

Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study

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Key result

Rising native T1 and ECV link to early mortality in anthracycline-induced cardiotoxicity.

n=31

Why the study?

Do cardiac MRI parameters (native T1 and ECV) predict early mortality in a preclinical model of anthracycline-induced cardiotoxicity?

Key Points

To evaluate the prognostic value of cardiac MRI parameters, specifically native T1 and extracellular volume fraction (ECV), for predicting early mortality in anthracycline-induced cardiotoxicity.
Administered weekly intravenous doxorubicin (2 mg/kg) to Sprague-Dawley rats (N=31) for up to 12 weeks, following them until natural death.
Performed cardiac MRI with parametric mapping sequences and post-mortem myocardial histology, evaluating associations with early mortality using Cox proportional hazards regression with time-dependent covariates.
Early mortality before 12 weeks occurred in 55% of animals (17 of 31 rats), whereas 14 rats survived to study completion.
In the early death group, native T1 significantly increased from 1210.51 ± 53.75 msec to 1368.09 ± 60.11 msec and extracellular volume fraction increased from 17.52% ± 2.05% to 21.63% ± 2.22% between weeks 4 and 6.

Structured PICO

Do cardiac MRI parameters (native T1 and ECV) predict early mortality in a preclinical model of anthracycline-induced cardiotoxicity?

P

Population

31 Sprague-Dawley rats receiving weekly intravenous doxorubicin injections for up to 12 weeks to evaluate cardiac MRI parameters for predicting early mortality.

E

Exposure

Cardiac MRI, including parametric mapping sequences (native T1 and extracellular volume fraction [ECV])

O

Outcome

Early mortality (death before 12 weeks)hard clinical

Cardiac MRI parameters, specifically native T1 and ECV, show potential for predicting early mortality in a preclinical model of anthracycline-induced cardiotoxicity.

Implication

Should not yet inform clinical cardio-oncology monitoring; leaves open predictive value of CMR T1/ECV in human doxorubicin cardiotoxicity.

Abstract

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Discussion

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Cite This Study

Kim et al. (2026) studied Anthracycline-induced cardiotoxicity (n=31). Cardiac MRI parameters (native T1 and ECV) was evaluated on Early mortality (before 12 weeks). In a preclinical model of anthracycline-induced cardiotoxicity, native T1 and extracellular volume fraction increased between weeks 4 and 6 in rats that experienced early mortality.

synapsesocial.com/papers/69fed021b9154b0b8287733f https://doi.org/10.1148/ryct.240525

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Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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