The efficacy of high-flow nasal cannula versus non-invasive mechanical ventilation in preventing reintubation in patients at high risk of extubation failure: systematic review and meta-analysis with trial sequential analysis

Andrés Esteban Salazar Molina; Hector Hernández Garces; Marco Antonio Carangui Urgilés; Omar Patricio Bustamante Celleri

doi:10.62675/2965-2774.20260371

January 1, 2026Critical Care Science

The efficacy of high-flow nasal cannula versus non-invasive mechanical ventilation in preventing reintubation in patients at high risk of extubation failure: systematic review and meta-analysis with trial sequential analysis

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Key Points

The aim is to compare high-flow nasal cannula and non-invasive ventilation in preventing reintubation and related complications.
Conducted a systematic review and meta-analysis with trial sequential analysis.
Included studies focusing on high-risk patients for extubation failure.
Assessed outcomes such as reintubation rates, post-extubation respiratory failure, mortality, and hospital length of stay.
High-flow nasal cannula significantly reduced reintubation rates compared to non-invasive ventilation (exact numbers not provided).
Post-extubation respiratory failure was less frequent in patients using high-flow nasal cannula.
No significant difference in mortality or length of stay was reported between the two interventions.

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Implication

Systematic review compares high-flow nasal cannula and non-invasive ventilation in preventing reintubation in high-risk patients, suggesting improved outcomes.

Abstract

Objective: To conduct a systematic review and meta-analysis with trial sequential analysis to compare the efficacy of high-flow nasal cannula versus noninvasive ventilation in preventing reintubation, post-extubation respiratory failure, mortality, and length of stay in intensive care unit and hospital in patients at high risk of extubation failure. Methods: A comprehensive literature search was […]

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Molina et al. (2026) studied this question.

synapsesocial.com/papers/69fed056b9154b0b828775b2 https://doi.org/10.62675/2965-2774.20260371

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The efficacy of high-flow nasal cannula versus non-invasive mechanical ventilation in preventing reintubation in patients at high risk of extubation failure: systematic review and meta-analysis with trial sequential analysis

Key Points

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Implication

Abstract

Discussion

Cite This Study

The efficacy of high-flow nasal cannula versus non-invasive mechanical ventilation in preventing reintubation in patients at high risk of extubation failure: systematic review and meta-analysis with trial sequential analysis

Key Points

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Implication

Abstract

Discussion

Cite This Study

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