What question did this study set out to answer?

This research aims to understand factors affecting iron mobilization in transfusion-dependent β-thalassemia despite chelation therapy.

Apparent plateaus during iron chelation in transfusion-dependent β-thalassemia: interpretation and clinical implications

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Narrative review evaluates iron chelation outcomes in transfusion-dependent β-thalassemia, highlighting implications for practice.

This research aims to understand factors affecting iron mobilization in transfusion-dependent β-thalassemia despite chelation therapy.
Conducted a narrative review of pivotal randomized trials and observational studies from 2000 to February 2026.
Evaluated therapies including deferoxamine, deferiprone, and deferasirox, focusing on MRI metrics for liver iron concentration and cardiac health.
Integrated transfusion iron input with serial MRI data to assess iron mobilization challenges.
Identified potential stagnation of iron removal in patients, referred to as a 'biological ceiling' leading to chronic iron overload.
Emphasized the need for tailored chelation strategies based on dominant organ risk and iron compartment saturation.

Delicou et al. (2026) studied this question.

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