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May 9, 2026Organic Letters1 citations

Electrochemically Driven, p K a -Controlled Regioselective Selenocyclization: Synthesis of Isocoumarin-1-imines with Structural Validation

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RZR N ZhangChina Agricultural UniversityYZYi ZhouChina Agricultural UniversityZWZhanzhou WeiChina Agricultural University

Key Points

  • The aim is to explore an electrochemical method for synthesizing isocoumarin-1-imines via regioselective selenocyclization.
  • Gram-scale synthesis conducted
  • Bioassays performed to test fungicidal activity
  • Regioselective methodology applied for structural validation
  • Successful synthesis of isocoumarin-1-imines observed
  • Preliminary bioassays reveal potential fungicidal activity
  • Structural validation supports the effectiveness of the method

Abstract

-attack pathway. The gram-scale synthesis and preliminary bioassays for fungicidal activity demonstrate the potential applications of this method.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fed071b9154b0b828778dahttps://doi.org/10.1021/acs.orglett.6c01485
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