A novel bile salt hydrolase-producing Ligilactobacillus salivarius prevents diet-induced obesity via regulation of bile acid metabolism and glucagon-like peptide 1 restoration

Key Points

The aim is to investigate the effects of Ligilactobacillus salivarius on bile acid metabolism and its role in preventing obesity.
Evaluated the impact of Ligilactobacillus salivarius on bile acid metabolism through controlled dietary interventions.
Assessed the restoration of glucagon-like peptide 1 levels as a mechanism of action.
Ligilactobacillus salivarius significantly altered bile acid metabolism, leading to reduced obesity markers.
Glucagon-like peptide 1 levels were restored, contributing to improved metabolic effects.

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Finds bile salt hydrolase-producing Ligilactobacillus salivarius regulates bile metabolism, implying potential for obesity prevention.

XA1416 as a promising anti-obesity probiotic, with UDCA serving as a key microbial metabolite that mediates its beneficial metabolic effects.

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Lv et al. (2026) studied this question.

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