A novel bile salt hydrolase-producing Ligilactobacillus salivarius prevents diet-induced obesity via regulation of bile acid metabolism and glucagon-like peptide 1 restoration

Key Points

• The aim is to investigate the effects of Ligilactobacillus salivarius on bile acid metabolism and its role in preventing obesity.
• Evaluated the impact of Ligilactobacillus salivarius on bile acid metabolism through controlled dietary interventions.
• Assessed the restoration of glucagon-like peptide 1 levels as a mechanism of action.
• Ligilactobacillus salivarius significantly altered bile acid metabolism, leading to reduced obesity markers.
• Glucagon-like peptide 1 levels were restored, contributing to improved metabolic effects.