On stepwise MTPs between Holm’s step-down MTP and the max- p -value MTP for co-primary endpoints: A further extension for free

Key Points

• This work aims to extend statistical methodologies for testing co-primary endpoints using stepwise multiple testing procedures.
• Introduces a new approach to stepwise multiple testing procedures (MTPs) between Holm's step-down MTP and the max-p-value MTP.
• Analyzes statistical performance through theoretical derivations and simulations.
• Shows improved power in detecting differences when using the extended stepwise MTPs.
• Demonstrates that the new procedures effectively maintain type I error rates across various scenarios.