What question did this study set out to answer?

Investigate how interdisciplinary approaches can improve clinical applications of phage therapy to combat infections.

May 9, 2026Nature Communications2 citationsOpen Access

From hype to hope: reanimating phage therapy through evidence-based multidisciplinarity

AFAleksandra Petrović FabijanThe University of Sydney SAS. T. AbedonThe Ohio State University at Mansfield

Key Points

Investigate how interdisciplinary approaches can improve clinical applications of phage therapy to combat infections.
Identified three foundational pillars: drug delivery, treatment effectiveness, and managing bacterial resistance.
Recommended interdisciplinary collaboration among various fields to enhance phage therapy research.
Critically analyzed existing evidence to propose pathways for better adoption of phage therapy.
Improved understanding of drug delivery mechanisms enhances efficacy of phage therapy in clinical settings.
Addressing treatment effectiveness leads to more consistent patient outcomes.
Strategies for managing bacterial resistance are essential for phage therapy to be a reliable option against infections.

Abstract

Abstract Phage therapy must move beyond anecdote to clinical reproducibility. Despite compelling cases of bacteriophages curing otherwise untreatable infections, inconsistent outcomes and biological complexity continue to limit clinical adoption. Here we identify three foundational pillars–drug delivery, treatment effectiveness, and managing bacterial resistance that must be addressed through interdisciplinary collaboration to transform phage therapy from a niche intervention to a powerful weapon against antimicrobial resistance. The time for rigorous, translational phage science is now.

AI에게 질문

Bookmark

View Full Paper