Key result
PRESSURE trial outlines methodology to compare permissive MAP targets versus usual care in critically ill children.
Why the study?
Does adjustment of hemodynamic support to achieve a permissive MAP target greater than the fifth centile for age improve a composite of 30-day mortality and duration of IMV in critically ill children on IMV and receiving vasoactive drugs for hypotension compared to usual care?
RCT
Open-label
parallel group
Yes
Does adjustment of hemodynamic support to achieve a permissive MAP target greater than the fifth centile for age improve a composite of 30-day mortality and duration of IMV in critically ill children on IMV and receiving vasoactive drugs for hypotension compared to usual care?
This paper describes the statistical analysis plan for the PRESSURE trial, which will evaluate whether a permissive blood pressure target improves outcomes in critically ill children.
Clinicians should retain usual MAP targets in critically ill children; this SAP extends transparent RCT evaluation of permissive hypotension.
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Viola et al. (2026) conducted an RCT in hypotension in critically ill children. permissive mean arterial pressure (MAP) target greater than the fifth centile for age vs. usual care was evaluated on composite 30-day mortality and duration of IMV. The statistical analysis plan for the PRESSURE trial outlines the methodology to compare a permissive MAP target versus usual care in critically ill children, with no results reported yet.
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