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May 9, 2026Biomacromolecules0 citations

PeptoBrush Enables Sustained Release of Auger Radiotherapeutic 125 IIododeoxyuridine for Glioblastoma Treatment

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GSGabriela SchäferLeiden UniversityQTQing TangMental Research InstituteHZHeyang ZhangLeiden University

Key Points

  • This research aims to evaluate the effectiveness of PeptoBrush for controlled release of iododeoxyuridine in glioblastoma treatment.
  • Assessed sustained release profile of iododeoxyuridine using PeptoBrushes.
  • Conducted DNA incorporation assays in glioblastoma cells to test biological activity.
  • Performed viability studies to evaluate radiotoxicity of the released compound.
  • Demonstrated sustained release of iododeoxyuridine from PeptoBrushes.
  • Confirmed biological activity with successful DNA incorporation in glioblastoma cells.
  • Observed significant radiotoxicity of the released compound in viability studies.

Abstract

I]IUdR, supporting a sustained release profile. DNA incorporation assays and viability studies in glioblastoma cells confirmed the biological activity and radiotoxicity of the released compound. This work highlights the potential of PeptoBrushes for controlled radionuclide delivery of Auger-emitting radiotherapeutic agents, laying the foundation for an innovative strategy in glioblastoma therapy.

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Cite This Study

Schäfer et al. (2026) studied this question.

synapsesocial.com/papers/69fed0c1b9154b0b82877ea7https://doi.org/10.1021/acs.biomac.5c02708
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