242 Bridging the gap: Aligning community and state public health goals with CTSA hub activities through indicator mapping

Objectives/Goals: To assess the feasibility and utility of using the community-informed Healthy North Carolina 2030 (HNC 2030) goals as a framework to evaluate CTSA-supported research; identify where NC CTSAs align with state health priorities; and enhance evaluation, planning, and communication of impact. Methods/Study Population: Three North Carolina CTSA hubs (UNC-Chapel Hill, Duke University, and Wake Forest University) collaboratively examined how the HNC 2030 indicators could be applied as an impact evaluation framework. Each hub independently identified projects with demonstrated or potential alignment to one or more HNC 2030 goals using institutional databases, project records, and stakeholder input. The feasibility and utility of this approach were assessed through structured reflections on practicality, appropriateness, and usefulness. Representative cases illustrate how alignment decisions were applied across clinical and public health domains. Results/Anticipated Results: Findings indicate that mapping CTSA activities to state health priorities is feasible, minimally burdensome, and adaptable across institutional contexts. The process identified both areas of strong engagement (e.g., maternal health, adolescent reproductive care) and opportunities for further investment (e.g., social determinants of health). Challenges included defining alignment boundaries, addressing cross-cutting indicators, and distinguishing between demonstrated and potential impact. This approach could strengthen communication of translational impact and inform strategic planning, helping CTSA hubs demonstrate the relevance of their work to statewide health goals. Discussion/Significance of Impact: Using community-driven state public health goals as an organizing framework enhances the relevance, transparency, and accountability of translational research. This exploratory mapping approach offers a scalable model for other CTSAs seeking to evaluate and communicate population-level impact.