Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension (SHAMROC): an open-label, randomized controlled trial

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Key Points

This study evaluates how different fluid resuscitation strategies affect long-term outcomes in patients with sepsis-induced hypotension.
Randomized controlled trial design with early restrictive versus liberal fluid strategies.
Participants were sepsis patients from the CLOVERS trial with long-term follow-up at 6 and 12 months.
Analyses used trimmed means to account for deceased patients.
At 6 months, no significant differences in cognitive function (Montreal Cognitive Assessment, trimmed mean difference 0.11, 95% CI -1.44-1.70).
No group differences in mobility (PROMIS Mobility Score, trimmed mean difference 0.72, 95% CI -2.20-3.64) and quality of life (EQ-5D-5L, trimmed mean difference -0.01, 95% CI -0.07-0.06) were found.
Similar findings occurred at 12 months; no significant advantages for either fluid strategy.

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Randomized trial assesses fluid strategy effects on long-term outcomes in sepsis survivors, indicating no group differences.

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Jorda et al. (2026) studied this question.

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