Enantioselective Iridium-Catalyzed Intramolecular Hydroarylation of (Hetero)Arene-Tethered Prochiral Diketones

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Enantioselective iridium-catalyzed intramolecular hydroarylation of (hetero)arene-tethered prochiral diketones is accelerated by a silane additive and proceeds via a carbometalation/O-H reductive elimination pathway. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Andrés Arribas; Carlos Lázaro-Milla; Martín Calvelo; José L Mascareñas; Fernando López

doi:10.1021/jacs.6c05640

May 7, 2026Journal of the American Chemical SocietyOpen Access

Enantioselective Iridium-Catalyzed Intramolecular Hydroarylation of (Hetero)Arene-Tethered Prochiral Diketones

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Key Points

The aim is to investigate the enantioselective hydroarylation of (hetero)arene-tethered prochiral diketones using iridium catalysts.
Utilized SiH as an additive to enhance reaction efficiency.
Conducted computational studies to explore the mechanism of the reaction.
Investigated stereo-selectivity through a carbometalation pathway.
Achieved high enantioselectivity in the hydroarylation process.

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Implication

Explores enantioselectivity in hydroarylation of prochiral diketones, indicating potential for enhanced synthesis.

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Arribas et al. (2026) studied this question.

synapsesocial.com/papers/69fed140b9154b0b828786f4 https://doi.org/10.1021/jacs.6c05640

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Enantioselective Iridium-Catalyzed Intramolecular Hydroarylation of (Hetero)Arene-Tethered Prochiral Diketones

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Implication

Abstract

Discussion

Cite This Study

Enantioselective Iridium-Catalyzed Intramolecular Hydroarylation of (Hetero)Arene-Tethered Prochiral Diketones

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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