What question did this study set out to answer?

To develop a rapid and efficient HPLC-ELSD method for inulin detection in pharmaceutical products.

May 9, 2026Results in ChemistryOpen Access

Development and validation of an enhanced resource efficient high performance liquid chromatography (HPLC)- evaporative light scattering detector (ELSD) method for determination of inulin in pharmaceutical formulations

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Randomized trial demonstrates efficient detection of inulin in pharmaceutical formulations, highlighting simplicity and sustainability.

To develop a rapid and efficient HPLC-ELSD method for inulin detection in pharmaceutical products.
Developed HPLC method using a C18 reverse phase column and water/methanol as mobile phase.
Validated according to ICH Q2 (R2) guidelines for linearity, LOD, and LOQ.
Applied method for analysis of inulin in inulin acetate tablets post in vitro release study.
Method shows linearity over 10-80 μg/mL with R²=0.998.
LOD of 10.41 μg/mL and LOQ of 31.57 μg/mL achieved.
Validated method demonstrates resource efficiency and suitability for routine quality control.

Das et al. (2026) studied this question.

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