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May 9, 2026Open Access

Anatomical Impact of Long-Term Psychological Stress on the Hippocampus and Interneuronal Connections: A Neuroanatomical Review

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Authors

GMGulshaxnoza MuhammadiyevaOUOzodbek Usmonov

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Overview

Neuroanatomical review reveals stress-induced changes in hippocampal structures, indicating cognitive decline implications.

Key Points

  • The study aims to explore how chronic psychological stress affects the structure and connections within the hippocampus.
  • In-depth neuroanatomical analysis synthesizing literature from 2020 to 2026
  • Focus on the HPA axis and its impact on dendritic atrophy
  • Examination of synaptic density loss in CA1 and CA3 hippocampal regions.
  • Chronic stress leads to significant dendritic atrophy in the hippocampus
  • Neurogenesis is suppressed due to stress exposure
  • Loss of synaptic density in CA1 and CA3 regions disrupts interneuronal networks.

Cite This Study

Muhammadiyeva et al. (2026) studied this question.

synapsesocial.com/papers/69fed153b9154b0b82878921https://doi.org/10.5281/zenodo.20064829
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