106 Allostatic load and hypertensive disorders of pregnancy: A scoping review

Objectives/Goals: Black women are adversely affected by HDP. Allostatic load is linked to poor pregnancy outcomes in Black women, but studies on its relation to HDP are limited and inconsistent, especially regarding racial disparities. The review aims to examine existing research on the association between allostatic load and HDP. Methods/Study Population: For this SCOPING review, a comprehensive search will be conducted of peer-reviewed literature in PubMed, Medline, Ovid Embase, Cochrane Library, and Google Scholar from database inception to October 1st, 2025. Relevant search terms will be used to identify studies that measure the exposure of allostatic load, a marker of chronic stress and the outcomes of hypertensive disorders of pregnancy, including preeclampsia, hypertension, and high blood pressure. Studies that discuss chronic stress as an exposure will also be included as a proxy measure of allostatic load. Inclusion criteria include a population of pregnant women and the availability of the study in English. This review will be conducted according to PRISMA guidelines. Results/Anticipated Results: This project is ongoing. Findings from this review will highlight the current landscape of literature exploring the association between allostatic load and HDP. Results will be organized into studies on allostatic load and HDP, chronic stress and HDP, and studies exploring racial differences in this association. Based on the findings, we hypothesize a correlation between allostatic load and HDP throughout the literature, with a particularly strong association observed among Black women. Discussion/Significance of Impact: The results of this review will offer insights into the relationship between allostatic load and HDP. This study will help establish a foundation for future research exploring this association and make the case for stress-reducing interventions as strategies to decrease racial disparities in maternal morbidity related to stress and HDP.