What question did this study set out to answer?

This study aims to uncover the function of ubiquitin-specific protease 11 (USP11) in renal interstitial fibroblasts and its signaling mechanisms.

May 9, 2026Renal FailureOpen Access

Ubiquitin-specific protease 11 facilitates the activation and proliferation of renal interstitial fibroblasts through epidermal growth factor receptor signaling pathways

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Randomized trial evaluates USP11's role in renal interstitial fibroblast activation, suggesting new treatment strategies for chronic kidney disease.

This study aims to uncover the function of ubiquitin-specific protease 11 (USP11) in renal interstitial fibroblasts and its signaling mechanisms.
Cultured NRK-49F fibroblasts were exposed to uric acid under varying concentrations and time periods.
Genetic and pharmacological depletion of USP11 was performed to assess its effects on fibroblast activation.
Mechanistic studies evaluated the phosphorylation of epidermal growth factor receptor and downstream signaling pathways.
Uric acid increased USP11 levels in fibroblasts by approximately 3-4 fold.
Depleting USP11 led to a 70-90% reduction in α-SMA and collagen I expressions.
USP11 activation enhanced phosphorylation of epidermal growth factor receptor and its downstream pathways, promoting fibroblast proliferation.

Ma et al. (2026) studied this question.

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Randomized trial evaluates USP11's role in renal interstitial fibroblast activation, suggesting new treatment strategies for chronic kidney disease.