Case report demonstrates 18F-FDG PET/CT shows greater efficacy in detecting prostate squamous cell carcinoma, suggesting better probe selection strategies.
Prostate squamous cell carcinoma (PSCC) is a rare and highly aggressive malignant tumor with a poor prognosis. We present a case of PSCC involving the entire prostate, seminal vesicles, and bladder, with lymph node metastases, as well as bilateral ureteral obstruction. A 45-year-old male patient underwent sequential 68 Ga-prostate-specific membrane antigen (PSMA) and 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The prostate tumor and all metastatic lesions showed low 68 Ga-PSMA uptake but intense 18 F-FDG avidity. This case highlights the potential advantage of 18 F-FDG PET/CT over 68 Ga-PSMA PET/CT in evaluating PSCC, and underscores the importance of integrating tumor marker profiles to guide appropriate probe selection.
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Yang et al. (2026) studied this question.
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